President Donald Trump has pulled out of his first trip to Latin America and is sending Mike Pence to the Summit of the Americas instead.
Mr Trump becomes the first US president not to attend the regional gathering since it was founded 24 years ago.
The White House said on Tuesday morning that the president was staying in Washington to deal with the Syria crisis.
“President Trump will not attend the 8th Summit of the Americas in Lima, Peru or travel to Bogota, Colombia as originally scheduled,” said Sarah Huckabee Sanders, the press secretary.
“At the president’s request, the vice president will travel in his stead.
“The president will remain in the United States to oversee the American response to Syria and to monitor developments around the world.”
John Bolton, who on Monday became Mr Trump’s national security adviser, urged Mr Trump to stay in Washington, White House officials told AP.
Mr Pence has previously served as Mr Trump’s envoy to Latin America, visiting Argentina, Chile, Colombia and Panama on a mission to “increase the pressure against the Maduro regime and negotiate better trade deals that benefit American workers,” according to Mr Pence’s spokesman.